Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | - |
Mycobacterium lentiflavum | |
6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | - |
Mycobacterium triplex | |
6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | - |
Mycobacterium tuberculosis | |
6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | - |
Mycobacterium lentiflavum | |
6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | - |
Mycobacterium triplex | |
6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | - |
Mycobacterium tuberculosis | |
alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | - |
Mycobacterium lentiflavum | |
alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | - |
Mycobacterium triplex | |
alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | - |
Mycobacterium tuberculosis | |
additional information | synthesis of alpha,alpha-trehalose derivatives, overview. These partly non-hydrolyzable substrate analogues act as inhibitors of the enzyme | Mycobacterium lentiflavum | |
additional information | synthesis of alpha,alpha-trehalose derivatives, overview. These partly non-hydrolyzable substrate analogues act as inhibitors of the enzyme | Mycobacterium triplex | |
additional information | synthesis of alpha,alpha-trehalose derivatives, overview. These partly non-hydrolyzable substrate analogues act as inhibitors of the enzyme | Mycobacterium tuberculosis | |
validamycin A | - |
Mycobacterium lentiflavum | |
validamycin A | - |
Mycobacterium triplex | |
validamycin A | - |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.082 | - |
alpha,alpha-trehalose 6-phosphate | pH 8.0, 37°C, recombinant enzyme | Mycobacterium triplex | |
0.13 | - |
alpha,alpha-trehalose 6-phosphate | pH 8.0, 37°C, recombinant enzyme | Mycobacterium lentiflavum | |
0.647 | - |
alpha,alpha-trehalose 6-phosphate | pH 8.0, 37°C, recombinant enzyme | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha,alpha-trehalose 6-phosphate + H2O | Mycobacterium tuberculosis | - |
alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | Mycobacterium lentiflavum | - |
alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | Mycobacterium triplex | - |
alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | Mycobacterium tuberculosis H37Rv | - |
alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | Mycobacterium tuberculosis ATCC 25618 | - |
alpha,alpha-trehalose + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium lentiflavum | A0A0E4GVV3 | - |
- |
Mycobacterium triplex | A0A024JUE5 | - |
- |
Mycobacterium tuberculosis | P9WFZ5 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WFZ5 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WFZ5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha,alpha-trehalose 6-phosphate + H2O | - |
Mycobacterium tuberculosis | alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | - |
Mycobacterium lentiflavum | alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | - |
Mycobacterium triplex | alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | - |
Mycobacterium tuberculosis H37Rv | alpha,alpha-trehalose + phosphate | - |
? | |
alpha,alpha-trehalose 6-phosphate + H2O | - |
Mycobacterium tuberculosis ATCC 25618 | alpha,alpha-trehalose + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BN1232_01302 | - |
Mycobacterium lentiflavum |
BN973_01567 | - |
Mycobacterium triplex |
otsB2 | - |
Mycobacterium tuberculosis |
otsB2 | - |
Mycobacterium lentiflavum |
otsB2 | - |
Mycobacterium triplex |
TPP | - |
Mycobacterium tuberculosis |
TPP | - |
Mycobacterium lentiflavum |
TPP | - |
Mycobacterium triplex |
trehalose 6-phosphate phosphatase | - |
Mycobacterium tuberculosis |
trehalose 6-phosphate phosphatase | - |
Mycobacterium lentiflavum |
trehalose 6-phosphate phosphatase | - |
Mycobacterium triplex |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
37 | - |
assay at | Mycobacterium lentiflavum |
37 | - |
assay at | Mycobacterium triplex |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mycobacterium tuberculosis |
8 | - |
assay at | Mycobacterium lentiflavum |
8 | - |
assay at | Mycobacterium triplex |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.228 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium triplex | alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | |
0.421 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium triplex | 6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | |
0.569 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium lentiflavum | alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | |
0.685 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium tuberculosis | alpha-D-glucopyranosyl 6,7-dideoxy-7-phosphono-alpha-D-gluco-heptopyranoside | |
1.031 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium lentiflavum | 6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | |
1.795 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium tuberculosis | 6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | |
1.959 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium triplex | 6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | |
2.198 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium tuberculosis | 6-deoxy-6-(phosphonoaminomethyl)-alpha,alpha-trehalose | |
3.287 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium lentiflavum | 6-deoxy-6-(phosphonomethyl)-alpha,alpha-trehalose | |
12.63 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium triplex | validamycin A | |
13.39 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium tuberculosis | validamycin A | |
15 | - |
pH 8.0, 37°C, recombinant enzyme | Mycobacterium lentiflavum | validamycin A |